Computer planning of stereotactic iodine-125 seed brachytherapy for recurrent malignant gliomas

Hughes, Stephen W., Sofat, Ajit, Kitchen, Neil D., Brown, Andrew, Beaney, Ron P., Timothy, Adrian R., Saunders, John E., & Thomas, David G. T. (1995) Computer planning of stereotactic iodine-125 seed brachytherapy for recurrent malignant gliomas. The British Journal of Radiology, 68(Feb), pp. 175-181.

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At St Thomas' Hospital, we have developed a computer program on a Titan graphics supercomputer to plan the stereotactic implantation of iodine-125 seeds for the palliative treatment of recurrent malignant gliomas. Use of the Gill-Thomas-Cosman relocatable frame allows planning and surgery to be carried out at different hospitals on different days. Stereotactic computed tomography (CT) and positron emission tomography (PET) scans are performed and the images transferred to the planning computer. The head, tumour and frame fiducials are outlined on the relevant images, and a three-dimensional model generated. Structures which could interfere with the surgery or radiotherapy, such as major vessels, shunt tubing etc., can also be outlined and included in the display. Catheter target and entry points are set using a three-dimensional cursor controlled by a set of dials attached to the computer. The program calculates and displays the radiation dose distribution within the target volume for various catheter and seed arrangements. The CT co-ordinates of the fiducial rods are used to convert catheter co-ordinates from CT space to frame space and to calculate the catheter insertion angles and depths. The surgically implanted catheters are after-loaded the next day and the seeds left in place for between 4 and 6 days, giving a nominal dose of 50 Gy to the edge of the target volume. 25 patients have been treated so far.

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ID Code: 49804
Item Type: Journal Article
Refereed: Yes
Keywords: radiotherapy, brachytherapy, iodine 125, stereotactic, malignant glioma, GBM, neurosurgery
DOI: 10.1259/0007-1285-68-806-175
ISSN: 0007-1285
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Radiation Therapy (111208)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 1995 British Institute of Radiology
Deposited On: 23 Apr 2012 01:12
Last Modified: 02 May 2012 09:18

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