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Early local functional changes in the human diabetic retina : a global flash multifocal electroretinogram study

Lung, Jenny C.Y., Swann, Peter G., & Chan, Henry H.L. (2012) Early local functional changes in the human diabetic retina : a global flash multifocal electroretinogram study. Graefe's Archive for Clinical and Experimental Ophthalmology.

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Abstract

Purpose: To investigate early functional changes of local retinal defects in type II diabetic patients using the global flash multifocal electroretinogram (MOFO mfERG).

Methods: Thirty-eight diabetic patients and 14 age-matched controls were recruited. Nine of the diabetics were free from diabetic retinopathy (DR), while the remainder had mild to moderate non-proliferative diabetic retinopathy. The MOFO mfERG was performed at high (98%) and low (46%) contrast levels. MfERG responses were grouped into 35 regions for comparison with DR classification at those locations. Z-scores of the regional mfERG responses were compared across different types of DR defects.

Results: The mfERG waveform consisted of the direct component (DC) and the induced component (IC). Local reduction in DC and IC amplitudes were found in diabetic patients with and without DR. With increasing severity of retinopathy, there was a further deterioration in amplitude of both components. Under MOFO mfERG paradigm, amplitude was a useful screening parameter.

Conclusion: The MOFO mfERG can help in detecting early functional anomalies before the appearance of visible signs, and may assist in monitoring further functional deterioration in diabetic patients.

Impact and interest:

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ID Code: 49888
Item Type: Journal Article
Additional Information: Springer OnlineFirst publication
Keywords: Diabetes mellitus, Diabetic retinopathy, Electroretinogram, Global flash multifocal electroretinogram, Retinal adaptation, Retinal functions
DOI: 10.1007/s00417-012-2010-z
ISSN: 1435-702X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2012 Springer-Verlag
Copyright Statement: The original publication is available at SpringerLink http://www.springerlink.com
Deposited On: 27 Apr 2012 10:46
Last Modified: 01 May 2012 06:14

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