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The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

Wells, Christine , Salvage-Jones, Judith , Li, Xin , Hitchens, Kelly , Butcher, Suzanne , Murray, Rachael, Beckhouse, Anthony , Lo, Yu-Lan-Sandra , Manzanero, Silvia , Cobbold, Christian , Schroder, Kate , Ma, Bo , Orr, Sally , Stewart, Lauren , Lebus, Daniel , Sobieszczuk, Peter , Hume, David , Stow, Jennifer , Blanchard, Helen , & Ashman, Robert (2008) The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. The Journal of Immunology, 180(11), pp. 7404-7413.

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    Abstract

    The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-_ by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.

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    120 citations in Scopus
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    112 citations in Web of Science®

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    ID Code: 50306
    Item Type: Journal Article
    Additional URLs:
    ISSN: 1550-6606 (online) 0022-1767 (print)
    Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Receptors and Membrane Biology (060110)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Immunology not elsewhere classified (110799)
    Deposited On: 16 May 2012 12:13
    Last Modified: 20 Jun 2012 08:55

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