SNAREing immunity : the role of SNAREs in the immune system

Stow, Jennifer, Manderson, Anthony, & Murray, Rachael (2006) SNAREing immunity : the role of SNAREs in the immune system. Nature Reviews Immunology, 6, pp. 919-929.

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Abstract

The trafficking of molecules and membranes within cells is a prerequisite for all aspects of cellular immune functions, including the delivery and recycling of cell surface proteins, secretion of immune mediators, ingestion of pathogens and activation of lymphocytes. SNARE (soluble-N-ethylmaleimide-sensitive-factor accessory-protein receptor)-family members mediate membrane fusion during all steps of trafficking, and function in almost all aspects of innate and adaptive immune responses. Here, we provide an overview of the roles of SNAREs in immune cells, offering insight into one level at which precision and tight regulation are instilled on immune responses.

Impact and interest:

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137 citations in Web of Science®

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ID Code: 50308
Item Type: Journal Article
Refereed: Yes
DOI: 10.1038/nri1980
ISSN: 1474-1733
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Protein Trafficking (060108)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Immunology not elsewhere classified (110799)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 20 May 2012 23:07
Last Modified: 20 May 2012 23:07

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