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A role for the phagosome in cytokine secretion

Murray, Rachael, Kay, Jason G. , Sangermani, Daniele , & Stow, Jennifer L. (2005) A role for the phagosome in cytokine secretion. Science, 310(5753), pp. 1492-1495.

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Abstract

Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor α (TNFα) is trafficked from the Golgi to the recycling endosome (RE), where vesicle-associated membrane protein 3 mediates its delivery to the cell surface at the site of phagocytic cup formation. Fusion of the RE at the cup simultaneously allows rapid release of TNFα and expands the membrane for phagocytosis.

Impact and interest:

63 citations in Scopus
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125 citations in Web of Science®

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ID Code: 50445
Item Type: Journal Article
DOI: 10.1126/science.1120225
ISSN: 1095-9203
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Enzymes (060107)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Immunology not elsewhere classified (110799)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 21 May 2012 09:51
Last Modified: 20 Jun 2012 09:51

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