A Bias in ML Estimates of Branch Lengths in the Presence of Multiple Signals
Penny, D., White, W. T., Hendy, M. D., & Phillips, M.J. (2008) A Bias in ML Estimates of Branch Lengths in the Presence of Multiple Signals. Molecular Biology and Evolution, 25(2), pp. 239-242.
Sequence data often have competing signals that are detected by network programs or Lento plots. Such data can be formed by generating sequences on more than one tree, and combining the results, a mixture model. We report that with such mixture models, the estimates of edge (branch) lengths from maximum likelihood (ML) methods that assume a single tree are biased. Based on the observed number of competing signals in real data, such a bias of ML is expected to occur frequently. Because network methods can recover competing signals more accurately, there is a need for ML methods allowing a network. A fundamental problem is that mixture models can have more parameters than can be recovered from the data, so that some mixtures are not, in principle, identifiable. We recommend that network programs be incorporated into best practice analysis, along with ML and Bayesian trees.
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|Item Type:||Journal Article|
|Keywords:||Maximum likehood estimation, Mixture models, Multiple signals|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)|
|Divisions:||Current > Schools > School of Earth, Environmental & Biological Sciences|
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2008 Oxford University Press|
|Deposited On:||24 May 2012 15:01|
|Last Modified:||24 May 2012 15:01|
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