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An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts

Farrugia, B.L., Keddie, D.J., George, G.A., Lynam, E.C., Brook, M.A. , Upton, Z., & Dargaville, T.R. (2012) An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts. Journal of Biomedical Materials Research - Part A, 100A(7), pp. 1919-1927.

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Abstract

This study investigates the effect of well-defined poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) ABA linear block co-oligomers on the proliferation of human dermal fibroblasts. The co-oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic-lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co-oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down-regulation of fibroblast proliferation, and the ratio HLB/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures with highest efficiency to be determined. These results suggest the possible use of the PEG-PDMS-PEG block co-oligomers as an alternative to silicone gels for hypertrophic scar remediation.

Impact and interest:

1 citations in Scopus
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ID Code: 50573
Item Type: Journal Article
Additional Information: Export Date: 23 May 2012 Source: Scopus Article in Press CODEN: JBMRC Language of Original Document: English Correspondence Address: Dargaville, T.R.; Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland Unemail: t.dargaville@qut.edu.au
Keywords: Amphiphilic, Dermal fibroblast, Proliferation, Silicone, Siloxane oligomers
DOI: 10.1002/jbm.a.33310
ISSN: 1549-3296
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Schools > School of Biomedical Sciences
Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 WILEY PERIODICALS, INC.
Deposited On: 04 Jun 2012 09:07
Last Modified: 03 Jun 2013 20:45

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