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A tan in a test tube -in vitro models for investigating ultraviolet radiation-induced damage in skin

Fernandez, Tara L., Dawson, Rebecca A., Van Lonkhuyzen, Derek R., Kimlin, Michael G., & Upton, Zee (2012) A tan in a test tube -in vitro models for investigating ultraviolet radiation-induced damage in skin. Experimental Dermatology, 21(6), pp. 404-410.

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Abstract

Presently, global rates of skin cancers induced by ultraviolet radiation (UVR) exposure are on the rise. In view of this, current knowledge gaps in the biology of photocarcinogenesis and skin cancer progression urgently need to be addressed. One factor that has limited skin cancer research has been the need for a reproducible and physiologically-relevant model able to represent the complexity of human skin. This review outlines the main currently-used in vitro models of UVR-induced skin damage. This includes the use of conventional two-dimensional cell culture techniques and the major animal models that have been employed in photobiology and photocarcinogenesis research. Additionally, the progression towards the use of cultured skin explants and tissue-engineered skin constructs, and their utility as models of native skin's responses to UVR are described. The inherent advantages and disadvantages of these in vitro systems are also discussed.

Impact and interest:

2 citations in Scopus
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1 citations in Web of Science®

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ID Code: 50658
Item Type: Journal Article
Keywords: photobiology, dermatology, tissue engineering, skin biology, skin cancer, Ultraviolet radiation, Animal models
DOI: 10.1111/j.1600-0625.2012.01485.x
ISSN: 09066705
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Life Sciences
Copyright Owner: Copyright 2012 John Wiley & Sons A/S
Deposited On: 30 May 2012 08:08
Last Modified: 10 Oct 2012 11:33

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