Mesoporous bioactive glass scaffolds for efficient delivery of vascular endothelial growth factor
Wu, Chengtie, Fan, Wei, Chang, Jiang, & Xiao, Yin (2012) Mesoporous bioactive glass scaffolds for efficient delivery of vascular endothelial growth factor. Journal of Biomaterials Applications. (In Press)
In this article, we, for the first time, investigated mesoporous bioactive glass scaffolds for the delivery of vascular endothelial growth factor. We have found that mesoporous bioactive glass scaffolds have significantly higher loading efficiency and more sustained release of vascular endothelial growth factor than non-mesoporous bioactive glass scaffolds. In addition, vascular endothelial growth factor delivery from mesoporous bioactive glass scaffolds has improved the viability of endothelial cells. The study has suggested that mesopore structures in mesoporous bioactive glass scaffolds play an important role in improving the loading efficiency, decreasing the burst release, and maintaining the bioactivity of vascular endothelial growth factor, indicating that mesoporous bioactive glass scaffolds are an excellent carrier of vascular endothelial growth factor for potential bone tissue engineering applications.
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|Item Type:||Journal Article|
|Keywords:||Mesoporous bioactive glass, scaffolds, vascular endothelial growth factor delivery, tissue engineering|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)|
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2012|
|Deposited On:||27 Jul 2012 14:27|
|Last Modified:||31 Jul 2012 09:27|
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