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Mesoporous bioactive glass scaffolds for efficient delivery of vascular endothelial growth factor

Wu, Chengtie , Fan, Wei , Chang, Jiang , & Xiao, Yin (2013) Mesoporous bioactive glass scaffolds for efficient delivery of vascular endothelial growth factor. Journal of Biomaterials Applications, 28(3), pp. 367-374.

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Abstract

In this article, we, for the first time, investigated mesoporous bioactive glass scaffolds for the delivery of vascular endothelial growth factor. We have found that mesoporous bioactive glass scaffolds have significantly higher loading efficiency and more sustained release of vascular endothelial growth factor than non-mesoporous bioactive glass scaffolds. In addition, vascular endothelial growth factor delivery from mesoporous bioactive glass scaffolds has improved the viability of endothelial cells. The study has suggested that mesopore structures in mesoporous bioactive glass scaffolds play an important role in improving the loading efficiency, decreasing the burst release, and maintaining the bioactivity of vascular endothelial growth factor, indicating that mesoporous bioactive glass scaffolds are an excellent carrier of vascular endothelial growth factor for potential bone tissue engineering applications.

Impact and interest:

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ID Code: 50848
Item Type: Journal Article
Keywords: Mesoporous bioactive glass, scaffolds, vascular endothelial growth factor delivery, tissue engineering
DOI: 10.1177/0885328212453635
ISSN: 0885-3282
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 The Author(s)
Deposited On: 27 Jul 2012 14:27
Last Modified: 28 Aug 2013 15:05

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