Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells

Xiao, Yin & Chen, Jiezhong (2013) Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells. In Mesenchymal Stem Cells - Basics and Clinical Application I. Springer Berlin Heidelberg, pp. 153-176.

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Mesenchymal stem cells (MSCs) are undifferentiated, multi-potent stem cells with the ability to renew. They can differentiate into many types of terminal cells, such as osteoblasts, chondrocytes, adipocytes, myocytes, and neurons. These cells have been applied in tissue engineering as the main cell type to regenerate new tissues. However, a number of issues remain concerning the use of MSCs, such as cell surface markers, the determining factors responsible for their differentiation to terminal cells, and the mechanisms whereby growth factors stimulate MSCs. In this chapter, we will discuss how proteomic techniques have contributed to our current knowledge and how they can be used to address issues currently facing MSC research. The application of proteomics has led to the identification of a special pattern of cell surface protein expression of MSCs. The technique has also contributed to the study of a regulatory network of MSC differentiation to terminal differentiated cells, including osteocytes, chondrocytes, adipocytes, neurons, cardiomyocytes, hepatocytes, and pancreatic islet cells. It has also helped elucidate mechanisms for growth factor–stimulated differentiation of MSCs. Proteomics can, however, not reveal the accurate role of a special pathway and must therefore be combined with other approaches for this purpose. A new generation of proteomic techniques have recently been developed, which will enable a more comprehensive study of MSCs. Keywords

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ID Code: 50851
Item Type: Book Chapter
Keywords: Mesenchymal stem cells, Proteomics, Cell surface markers, Differentiation, Growth factors
DOI: 10.1007/10_2012_143
ISSN: 0724-6145
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Springer.
Deposited On: 08 May 2013 01:53
Last Modified: 19 Oct 2015 16:05

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