Additive manufacturing of tissues and organs

Melchels, Ferry P.W., Domingos, Marco Andre Neves, Klein, Travis J., Malda, Jos, Bartolo, Paulo J., & Hutmacher, Dietmar (2012) Additive manufacturing of tissues and organs. Progress in Polymer Science, 37(31), pp. 1079-1104.

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Additive manufacturing techniques offer the potential to fabricate organized tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations of cells along multiple axes with high geometric complexity in combination with different biomaterials can be generated. The level of control offered by these computer-controlled technologies to design and fabricate tissues will accelerate our understanding of the governing factors of tissue formation and function. Moreover, it will provide a valuable tool to study the effect of anatomy on graft performance. In this review, we discuss the rationale for engineering tissues and organs by combining computer-aided design with additive manufacturing technologies that encompass the simultaneous deposition of cells and materials. Current strategies are presented, particularly with respect to limitations due to the lack of suitable polymers, and requirements to move the current concepts to practical application.

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306 citations in Scopus
251 citations in Web of Science®
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ID Code: 51161
Item Type: Journal Article
Refereed: Yes
Additional Information: Topical Issue on Biorelated polymers
Additional URLs:
Keywords: Additive manufacturing, Bioprinting, Biofabrication, Hydrogels, Tissue engineering
DOI: 10.1016/j.progpolymsci.2011.11.007
ISSN: 1873-1619
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2011 Elsevier Ltd.
Copyright Statement: This is the author’s version of a work that was accepted for publication in Progress in Polymer Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Progress in Polymer Science, [VOL 37, ISSUE 31, (2012)] DOI: 10.1016/j.progpolymsci.2011.11.007
Deposited On: 27 Jun 2012 22:53
Last Modified: 01 Sep 2016 14:55

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