Fast fourier analysis of structural organization in decellularized cartilage-on-bone laminates
Heidarkhan Tehrani, Ashkan, Singh, Sanjleena, Xiao, Yin, & Oloyede, Adekunle (2012) Fast fourier analysis of structural organization in decellularized cartilage-on-bone laminates. In Merrell , R, Shin, D. G, & Hamza , M. H (Eds.) Proceedings of the IASTED International Symposia Imaging and Signal Processing in Health Care and Technology (ISPHT 2012), IEEE Engineering in Medicine and Biology Society , Baltimore, USA , pp. 71-77.
Denaturation of tissues can provide a unique biological environment for regenerative medicine application only if minimal disruption of their microarchitecture is achieved during the decellularization process. The goal is to keep the structural integrity of such a construct as functional as the tissues from which they were derived. In this work, cartilage-on-bone laminates were decellularized through enzymatic, non-ionic and ionic protocols. This work investigated the effects of decellularization process on the microarchitecture of cartiligous extracellular matrix; determining the extent of how each process deteriorated the structural organization of the network. High resolution microscopy was used to capture cross-sectional images of samples prior to and after treatment. The variation of the microarchitecture was then analysed using a well defined fast Fourier image processing algorithm. Statistical analysis of the results revealed how significant the alternations among aforementioned protocols were (p < 0.05). Ranking the treatments by their effectiveness in disrupting the ECM integrity, they were ordered as: Trypsin> SDS> Triton X-100.
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Conference Paper|
|Keywords:||Decellularization, Extracellular matrix, Image processing, Fast Fourier transform, Cartilage-on-bone laminate|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||02 Jul 2012 09:49|
|Last Modified:||13 Jun 2013 00:53|
Repository Staff Only: item control page