Anisotropy of articular cartilage reflects the ECM gradient architecture : Hough-Radon Transform Analysis
Heidarkhan Tehrani, Ashkan, Singh, Sanjleena, Xiao, Yin, & Oloyede, Adekunle (2012) Anisotropy of articular cartilage reflects the ECM gradient architecture : Hough-Radon Transform Analysis. In Merrell , R. (Ed.) Proceedings of the IASTED International Symposia Imaging and Signal Processing in Health Care and Technology (ISPHT 2012), ACTA Press, Baltimore, pp. 64-70.
Tissue-specific extracellular matrix (ECM) is known to be an ideal bioscaffold to inspire the future of regenerative medicine. It holds the secret of how nature has developed such an organization of molecules into a unique functional complexity. This work exploited an innovative image processing algorithm and high resolution microscopy associated with mechanical analysis to establish a correlation between the gradient organization of cartiligous ECM and its anisotropic biomechanical response. This was hypothesized to be a reliable determinant that can elucidate how microarchitecture interrelates with biomechanical properties. Hough-Radon transform of the ECM cross-section images revealed its conformational variation from tangential interface down to subchondral region. As the orientation varied layer by layer, the anisotropic mechanical response deviated relatively. Although, results were in good agreement (Kendall's tau-b > 90%), there were evidences proposing that alignment of the fibrous network, specifically in middle zone, is not as random as it was previously thought.
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|Item Type:||Conference Paper|
|Keywords:||Articular cartilage, Zonal organization, Hough-Radon transform, Image analysis, Mechanical properties|
|Subjects:||Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2012 ACTA Press|
|Deposited On:||02 Jul 2012 10:28|
|Last Modified:||11 Apr 2013 12:44|
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