Effect Of changes in sodium intake on cell transport parameters

Morgan, T. O., Myers, J. B., Edwards, K., Adam, W., & Wellard, R. M. (1984) Effect Of changes in sodium intake on cell transport parameters. Clinical and Experimental Hypertension, a6(1-2), pp. 455-467.

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Changing sodium intake from 70-200 mmol/day elevates blood pressure in normotensive volunteers by 6/4 mmHg. Older people, people with reduced renal function on a low sodium diet and people with a family history of hypertension are more likely to show this effect. The rise in blood pressure was associated with a fall in plasma volume suggesting that plasma volume changes do not initiate hypertension. In normotensive individuals the most common abnormality in membrane sodium transport induced by an extra sodium load was an increased permeability of the red cell to sodium. Some normotensive individuals also had an increase in the level of a plasma inhibitor that inhibited Na-K ATPase. These individuals also appeared to have a rise in blood pressure. Sodium intake and blood pressure are related. The relationship differs in different people and is probably controlled by the genetically inherited capacity of systems involved in membrane sodium transport.

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5 citations in Scopus
6 citations in Web of Science®
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ID Code: 51365
Item Type: Journal Article
Refereed: Yes
Keywords: Sodium Intake, Natriuretic Hormone, Sodium Efflux, Erythrocytes
DOI: 10.3109/10641968409062577
ISSN: 1525-6006
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 03 Jul 2012 00:32
Last Modified: 03 Jul 2012 00:32

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