Persistent digital hyperthermia over a 48 h period does not induce laminitis in horses
de Laat, Melody A., Pollitt, Christopher C., Walsh, Donald M., McGowan, Catherine M., & Sillence, Martin N. (2012) Persistent digital hyperthermia over a 48 h period does not induce laminitis in horses. The Veterinary Journal, 192(3), pp. 435-440.
Persistent digital hyperthermia, presumably due to vasodilation, occurs during the developmental and acute stages of insulin-induced laminitis. The objectives of this study were to determine if persistent digital hyperthermia is the principal pathogenic mechanism responsible for the development of laminitis.
The potent vasodilator, ATP-MgCl 2 was infused continuously into the distal phalanx of the left forefoot of six Standardbred racehorses for 48h via intra-osseous infusion to promote persistent digital hyperthermia. The right forefoot was infused with saline solution and acted as an internal control. Clinical signs of lameness at the walk were not detected at 0h, 24h or 48h post-infusion. Mean±SE hoof wall temperatures of the left forefoot (29.4±0.25°C) were higher (P<0.05) than those on the right (27.5±0.38°C). Serum insulin (15.0±2.89μIU/mL) and blood glucose (5.4±0.22mM) concentrations remained unchanged during the experiment. Histopathological evidence of laminitis was not detected in any horse.
The results demonstrated that digital vasodilation up to 30 °C for a period of 48. h does not trigger laminitis in the absence of hyperinsulinaemia. Thus, although digital hyperthermia may play a role in the pathogenesis of laminitis, it is not the sole mechanism involved.
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|Item Type:||Journal Article|
|Keywords:||Laminitis, ATP-MgCl2, Equine, Vasodilation, Intra-osseous, Hyperthermia|
|Divisions:||Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2011 Elsevier Ltd.|
|Copyright Statement:||This is the author's version of a work that was accepted for publication in The Veterinary Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Veterinary Journal, [Vol. 192, Issue. 3, June 2012] http://dx.doi.org/10.1016/j.tvjl.2011.09.016|
|Deposited On:||03 Jul 2012 22:44|
|Last Modified:||30 Aug 2013 14:13|
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