Evolutionary design of bone scaffolds with reference to material selection

Heljak, M. K., Świeszkowski, W., Lam, C. X. F., Hutmacher, Dietmar, & Kurzydlowski, K. J. (2012) Evolutionary design of bone scaffolds with reference to material selection. International Journal for Numerical Methods in Biomedical Engineering, 28(6-7), pp. 789-800.

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The favourable scaffold for bone tissue engineering should have desired characteristic features, such as adequate mechanical strength and three-dimensional open porosity, which guarantee a suitable environment for tissue regeneration. In fact, the design of such complex structures like bone scaffolds is a challenge for investigators. One of the aims is to achieve the best possible mechanical strength-degradation rate ratio. In this paper we attempt to use numerical modelling to evaluate material properties for designing bone tissue engineering scaffold fabricated via the fused deposition modelling technique. For our studies the standard genetic algorithm was used, which is an efficient method of discrete optimization. For the fused deposition modelling scaffold, each individual strut is scrutinized for its role in the architecture and structural support it provides for the scaffold, and its contribution to the overall scaffold was studied. The goal of the study was to create a numerical tool that could help to acquire the desired behaviour of tissue engineered scaffolds and our results showed that this could be achieved efficiently by using different materials for individual struts. To represent a great number of ways in which scaffold mechanical function loss could proceed, the exemplary set of different desirable scaffold stiffness loss function was chosen. © 2012 John Wiley & Sons, Ltd.

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ID Code: 51412
Item Type: Journal Article
Refereed: Yes
Additional Information: Export Date: 3 July 2012 Source: Scopus Language of Original Document: English Correspondence Address: Świeszkowski, W.; Faculty of Materials Science and Engineering, Warsaw University of TechnologyPoland; email: wswieszk@inmat.pw.edu.pl References: Chu, P.K., Liu, X., (2008) Biomaterials Fabrication and Processing Handbook, , CRC Press: Boca Raton; Zein, I., Hutmacher, D.W., Tan, K.C., Teoh, S.H., Fused deposition modeling of novel scaffold architectures for tissue engineering applications (2002) Biomaterials, 23, pp. 1169-1185; Shor, L., Guceri, S., Wen, X., Ghandi, M., Sun, W., Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro (2007) Biomaterials, 28, pp. 5291-5297; Wettergreen, M.A., Bucklen, B.S., Starly, B., Yuksel, E., Sun, W., Liebschner, M.A.K., Creation of a unit block library of architectures for use in assembled scaffold engineering (2005) Computer-Aided Design, 37, pp. 1141-1149; Hollister, S.J., Maddox, R.D., Taboas, J.M., Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints (2002) Biomaterials, 23, pp. 4095-4103; Adachi, T., Osako, Y., Tanaka, M., Hojo, M., Hollister, S.J., Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration (2006) Biomaterials, 27, pp. 3964-3972; Woodruff, M.A., Hutmacher, D.W., Return of forgotten polymer - Polycaprolactone in 21 st century (2010) Progress in Polymer Science, 35, pp. 1217-1256; Liu, F., A modified genetic algorithm for solving the inverse heat transfer problem of estimating plan heat source (2008) International Journal of Heat and Mass Transfer, 51, pp. 3745-3752; de Castro, L.N., Fundamentals of natural computing: an overview (2007) Physics of Life Reviews, 4, pp. 1-36; Michalewicz, Z., (1996) Genetic Algorithms+Data Structures=Evolutionary Programs, , Springer Verlag: Berlin; Ament, C., Hofer, E.P., A fuzzy logic model of fracture healing (2000) Journal of Biomechanics, 33, pp. 961-968; Shefelbine, S.J., Augat, P., Claes, L., Simon, U., Trabecular bone fracture healing simulation with finite element analysis and fuzzy logic (2005) Journal of Biomechanics, 38, pp. 2440-2450; Göpferich, A., Mechanisms of polymer degradation and erosion (1996) Biomaterials, 17, pp. 103-114; Wu, L., Ding, J., In vitro degradation of three-dimensional porous poly (D, L-lactide-co-glycolide) scaffolds for tissue engineering (2004) Biomaterials, 25, pp. 5821-5830; Middleton, J.C., Tipton, A.J., Synthetic biodegradable polymers as orthopedic devices (2000) Biomaterials, 21, pp. 2335-2346; Wirth, N., (1975) Algorithms+Data Structures=Programs, , Prentice-Hall Englewood Cliffs; Burczynski, T., Kus, W., Dlugosz, A., Orantek, P., Optimization and defect identification using distributed evolutionary algorithms (2004) Artificial Intelligence, 17, pp. 337-344; Cappello, F., Mancuso, A., A genetic algorithm for combined topology and shape optimisations (2003) Computer-Aided Design, 35, pp. 761-769; Kelly, D.J., Prendergast, P.J., Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects (2005) Journal of Biomechanics, 38, pp. 1413-1422; Andreykiv, A., Prendergast, P.J., van Keulen, F., Swieszkowski, W., Rozing, P.M., Bone ingrowth simulation for a concept glenoid component design (2005) Journal of Biomechanics, 38, pp. 1023-1033; van der Meulen, M.C.H., Huiskes, R., Why mechanobiology? A survey article (2002) Journal of Biomechanics, 35, pp. 401-414; Wang, Y., Pan, J., Han, X., Sinka, C., Ding, L., A phenomenological model for the degradation of biodegradable polymers (2008) Biomaterials, 29, pp. 3393-3401; Guldberg, R.E., Duvall, C.L., Peister, A., Oest, M.E., Lin, A.S.P., Palmer, A.W., Levenston, M., 3D imaging of tissue integration with porous biomaterials (2008) Biomaterials, 29, pp. 3757-3761
Keywords: FEM, Fused deposition modeling, Genetic algorithm, Scaffold
DOI: 10.1002/cnm.2487
ISSN: 2040-7947 (online) 2040-7939 (print)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 John Wiley & Sons, Ltd.
Deposited On: 04 Jul 2012 00:15
Last Modified: 12 Jun 2013 14:54

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