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An improved model of tumour-immune system interactions

Trisilowati,, McCue, Scott, & Mallet, Dann (2012) An improved model of tumour-immune system interactions. In Sri Wahyuni, (Ed.) Proceedings of the 6th Southeast Asian Mathematical Society – Gadjah Mada University International Conference on Mathematics and its Applications 2011, Yogyakarta University, Indonesia, pp. 895-904.

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Abstract

The immune system plays an important role in defending the body against tumours and other threats. Currently, mechanisms involved in immune system interactions with tumour cells are not fully understood. Here we develop a mathematical tool that can be used in aiding to address this shortfall in understanding. This paper de- scribes a hybrid cellular automata model of the interaction between a growing tumour and cells of the innate and specific immune system including the effects of chemokines that builds on previous models of tumour-immune system interactions. In particular, the model is focused on the response of immune cells to tumour cells and how the dynamics of the tumour cells change due to the immune system of the host. We present results and predictions of in silico experiments including simulations of Kaplan-Meier survival-like curves.

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ID Code: 51581
Item Type: Conference Paper
Keywords: hybrid cellular automata, tumour, chemokine, immune, dendritic cell, cytotoxic T lymphocyte
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2011 [please consult the author]
Deposited On: 13 Jul 2012 09:21
Last Modified: 23 Mar 2013 01:37

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