Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA
Gupta, Rajesh, Beck, Jennifer L. , Sheil, Margaret M. , & Ralph, Stephen F. (2005) Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA. Journal of Inorganic Biochemistry, 99(2), pp. 552-559.
A combination of enzymatic digestion and electrospray ionisation mass spectrometry (ESI-MS) was used to characterise bifunctional adducts in which cisplatin is bound to GA base sequences in 8mer and 16mer oligonucleotides that do not contain other, higher affinity binding sites. The extent of formation of bifunctional adducts with GA base sequences was significant, but less than that seen with similar oligonucleotides containing either AG or GG sequences.
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|Item Type:||Journal Article|
|Keywords:||DNA, cisplatin, mass spectrometry, ologonucleotides, ESI-MS|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Analytical Biochemistry (060101)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||17 Jul 2012 08:31|
|Last Modified:||26 Jul 2012 15:22|
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