Challenges to environmental toxicology and epidemiology : where do we stand and which way do we go?

Pesch, B., Brüning, T., Frentzel-Beyme, R., Johnen, G., Harth, V., Hoffmann, W., Ko, Y., Ranft, U., Traugott, U.G., Thier, R, Taeger, D., & Bolt, H.M. (2004) Challenges to environmental toxicology and epidemiology : where do we stand and which way do we go? Toxicology Letters, 151(1), pp. 255-266.

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Modern toxicology investigates a wide array of both old and new health hazards. Priority setting is needed to select agents for research from the plethora of exposure circumstances. The changing societies and a growing fraction of the aged have to be taken into consideration. A precise exposure assessment is of importance for risk estimation and regulation. Toxicology contributes to the exploration of pathomechanisms to specify the exposure metrics for risk estimation. Combined effects of co-existing agents are not yet sufficiently understood. Animal experiments allow a separate administration of agents which can not be disentangled by epidemiological means, but their value is limited for low exposure levels in many of today’s settings. As an experimental science, toxicology has to keep pace with the rapidly growing knowledge about the language of the genome and the changing paradigms in cancer development. During the pioneer era of assembling a working draft of the human genome, toxicogenomics has been developed. Gene and pathway complexity have to be considered when investigating gene–environment interactions. For a best conduct of studies, modern toxicology needs a close liaison with many other disciplines like epidemiology and bioinformatics.

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ID Code: 51635
Item Type: Journal Article
Refereed: Yes
Keywords: Exposure assessment; Gene–environment interaction; Toxicogenomics; Pathomechanism
DOI: 10.1016/j.toxlet.2004.02.020
ISSN: 0378-4274
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2004 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Toxicology Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Toxicology Letters, [VOL: 151, ISSUE: 1, (2004)] DOI: 10.1016/j.toxlet.2004.02.020
Deposited On: 17 Jul 2012 22:11
Last Modified: 17 Oct 2014 01:22

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