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Molecular investigation of the mechanical properties of single actin filaments based on vibration analyses

Li, Tong, Gu, YuanTong, Oloyede, Adekunle, & Yarlagadda, Prasad K. (2014) Molecular investigation of the mechanical properties of single actin filaments based on vibration analyses. Computer Methods in Biomechanics and Biomedical Engineering, 17(6), pp. 616-622.

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Abstract

The mechanical vibration properties of single actin filaments from 50 to 288 nm are investigated by the molecular dynamics simulation in this study. The natural frequencies obtained from the molecular simulations agree with those obtained from the analytical solution of the equivalent Euler–Bernoulli beam model. Through the convergence study of the mechanical properties with respect to the filament length, it was found that the Euler–Bernoulli beam model can only be reliably used when the single actin filament is of the order of hundreds of nanometre scale. This molecular investigation not only provides the evidence for the use of the continuum beam model in characterising the mechanical properties of single actin filaments, but also clarifies the criteria for the effective use of the Euler–Bernoulli beam model.

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ID Code: 51636
Item Type: Journal Article
Keywords: actin filament, mechanical vibration, flexural rigidity, Young's modulus, coarse-grained molecular dynamics
DOI: 10.1080/10255842.2012.706279
ISSN: 1025-5842
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 Taylor & Francis.
Copyright Statement: This is an Author's Accepted Manuscript of an article published in Computer Methods in Biomechanics and Biomedical Engineering [Volume 17, Issue 6, (2014)] [copyright Taylor & Francis], available online at: http://www.tandfonline.com/10.1080/10255842.2012.706279
Deposited On: 18 Jul 2012 08:16
Last Modified: 16 Apr 2014 11:08

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