Microstructural magnetic resonance imaging of articular cartilage
Momot, Konstantin I. (2012) Microstructural magnetic resonance imaging of articular cartilage. Biomedical Spectroscopy and Imaging, 1(1), pp. 27-37.
The focus of this Editorial is recent developments in magnetic resonance imaging (MRI) modalities for evaluation of the microstructure and macromolecular organisation of articular cartilage. We place a specific emphasis on three types of measurements:
(1) MRI transverse spin-relaxation mapping (T2 mapping);
(2) diffusion-tensor imaging; and
(3) compression micro-MRI (uMRI) measurements of articular cartilage in vitro.
Such studies have a significant role to play in improving the understanding of the fundamental biomechanics of articular cartilage and in the development of in vitro models of early osteoarthritis. We discuss how the supramolecular organisation of the cartilage extracellular matrix and its behaviour under mechanical compression can be inferred from diffusion-tensor and T2 maps with in-plane resolution ~100 um. The emphasis is on in vitro studies performed under controlled physiological conditions but in vivo applications of T2 mapping and DTI are also briefly discussed.
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|Item Type:||Journal Article|
|Keywords:||Diffusion tensor imaging, spin relaxation, Magnetic Resonance imaging, articular cartilage, collagen and proteoglycans|
|Subjects:||Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2012 IOS Press and the author|
|Copyright Statement:||All right reserved|
|Deposited On:||19 Jul 2012 13:26|
|Last Modified:||24 Jul 2012 20:40|
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