Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics

Chakraborty, Ranjay, Read, Scott, & Collins, Michael (2011) Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics. Investigative Ophthalmology and Visual Science, 52(8), pp. 5121-5129.

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Abstract

Purpose

  • To investigate the pattern of diurnal variations in axial length (AL), choroidal thickness, intraocular pressure (IOP), and ocular biometrics over 2 consecutive days.

Methods

  • Measurements of ocular biometrics and IOP were collected for 30 young adult subjects (15 myopes, 15 emmetropes) at 10 different times over 2 consecutive days. Five sets of measurements were collected each day at approximately 3-hour intervals, with the first measurement taken at ∼9 AM and final measurement at ∼9 PM.

Results

  • AL underwent significant diurnal variation (P < 0.0001) that was consistently observed across the 2 measurement days. The longest AL was typically observed at the second measurement session (mean time, 12:26) and the shortest AL at the final session of each day (mean time, 21:06). The mean diurnal change in AL was 0.032 ± 0.018 mm. Choroidal thickness underwent significant diurnal variation (mean change, 0.029 ± 0.016 mm; P < 0.001) and varied approximately in antiphase to the AL changes. Significant diurnal variations were also found in vitreous chamber depth (VCD; mean change, 0.06 ± 0.029 mm; P < 0.0001) and IOP (mean change, 3.54 ± 0.84 mm Hg; P < 0.0001). A positive association was found between the variations of AL and IOP (r2 = 0.17, P < 0.0001) and AL and VCD (r2 = 0.31, P < 0.0001) and a negative association between AL and choroidal thickness (r2 = 0.13, P < 0.0001). There were no significant differences in the magnitude and timing of diurnal variations associated with refractive error.

Conclusions

  • Significant diurnal variations in AL, choroidal thickness, and IOP were consistently observed over 2 consecutive days of testing.

Impact and interest:

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ID Code: 52381
Item Type: Journal Article
Refereed: Yes
DOI: 10.1167/iovs.11-7364
ISSN: 0146-0404
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: 2011 The Association for Research in Vision and Ophthalmology, Inc.
Deposited On: 19 Jul 2012 06:30
Last Modified: 16 Dec 2016 01:37

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