Persistence of multiple genetic lineages within intra-host populations of Ross River virus
Liu, Wen, Rourke, Michelle, Holmes, Edward, & Aaskov, John (2011) Persistence of multiple genetic lineages within intra-host populations of Ross River virus. Journal of Virology, 85(11), pp. 5674-5678.
We examined the structure and extent of genetic diversity in intrahost populations of Ross River virus (RRV) in samples from six human patients, focusing on the nonstructural (nsP3) and structural (E2) protein genes. Strikingly, although the samples were collected from contrasting ecological settings 3,000 kilometers apart in Australia, we observed multiple viral lineages in four of the six individuals, which is indicative of widespread mixed infections. In addition, a comparison with previously published RRV sequences revealed that these distinct lineages have been in circulation for at least 5 years, and we were able to document their long-term persistence over extensive geographical distances
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|Item Type:||Journal Article|
|Keywords:||Genetic diversity, Ross River virus , Alphaviruses, Intrahost|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500)
Australian and New Zealand Standard Research Classification > AGRICULTURAL AND VETERINARY SCIENCES (070000) > VETERINARY SCIENCES (070700)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL MICROBIOLOGY (110800)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||19 Jul 2012 06:31|
|Last Modified:||19 Sep 2013 01:56|
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