Computational fluid dynamic analysis of intracranial aneurysm bleb Formation (NS26P)
Russell, Jeremy, Hughes, Stephen W., Barry, Mark D., Kelson, Neil, Clouston, John, Coulthard, Alan, & Winter, Craig (2012) Computational fluid dynamic analysis of intracranial aneurysm bleb Formation (NS26P). In Royal Australasian College of Surgeons Annual Scientific Congress, 6 - 10 May 2012, Kuala Lumpur Convention Centre, Kuala Lumpur.
Purpose: The management of unruptured aneurysms remains controversial as treatment infers potential significant risk to the currently well patient. The decision to treat is based upon aneurysm location, size and abnormal morphology (e.g. bleb formation). A method to predict bleb formation would thus help stratify patient treatment. Our study aims to investigate possible associations between intra-aneurysmal flow dynamics and bleb formation within intracranial aneurysms. Competing theories on aetiology appear in the literature. Our purpose is to further clarify this issue.
Methodology: We recruited data from 3D rotational angiograms (3DRA) of 30 patients with cerebral aneurysms and bleb formation. Models representing aneurysms pre-bleb formation were reconstructed by digitally removing the bleb, then computational fluid dynamics simulations were run on both pre and post bleb models. Pulsatile flow conditions and standard boundary conditions were imposed.
Results: Aneurysmal flow structure, impingement regions, wall shear stress magnitude and gradients were produced for all models. Correlation of these parameters with bleb formation was sought. Certain CFD parameters show significant inter patient variability, making statistically significant correlation difficult on the partial data subset obtained currently.
Conclusion: CFD models are readily producible from 3DRA data. Preliminary results indicate bleb formation appears to be related to regions of high wall shear stress and direct impingement regions of the aneurysm wall.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Conference Item (Poster)|
|Keywords:||aneurysm, intracranial, bleb, computational fluid dynamics|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Surgery (110323)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering|
Current > QUT Faculties and Divisions > Division of Technology, Information and Learning Support
Current > Research Centres > High Performance Computing and Research Support
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||10 Aug 2012 08:14|
|Last Modified:||12 Nov 2014 08:34|
Repository Staff Only: item control page