A DRD2 and ANKK1 haplotype is associated with nicotine dependence
Voisey, Joanne, Swagell, Christopher Dean, Hughes, Ian Paul, van Daal, Angela, Noble, Ernest Pascal, Lawford, Bruce Robert, Young, Ross McDonald, & Morris, Charles Phillip (2012) A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Psychiatry Research, 196(2-3), pp. 285-289.
To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the DRD2 C957T, -141delC and ANKK1 TaqIA polymorphisms (rs6277, rs1799732 and rs1800497, respectively). The -141delC SNP did not show any association but both the C957T and TaqIA SNPs showed association at the allele, genotype, haplotype and combined genotype levels. The 957C/TaqI A1 haplotype was more than 3.5 times as likely to be associated with nicotine dependence compared with the 957T/TaqI A1 haplotype (P = 0.003). Analysis of the combined genotypes of both SNPs revealed that individuals who were homozygous for the 957C-allele (CC) and had either one or two copies of the TaqI A1-allele were 3.3 times as likely to have nicotine dependence compared to all other genotype combinations (P = 0.0003) and that these genotypes accounted for approximately 13% of the susceptibility to nicotine addiction in our population. Our findings suggest that the DRD2 C957T polymorphism and the ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.
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|Item Type:||Journal Article|
|Keywords:||genetic association, Dopamine D2 receptor, ANKK1, Addiction, Haplotype|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Neurogenetics (060410)|
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
|Copyright Owner:||Copyright 2012 Elsevier Ireland Ltd. All rights reserved.|
|Copyright Statement:||This is the author’s version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research, Volume 196, Issues 2–3, 30 April 2012, Pages 285–289, DOI: 10.1016/j.psychres.2011.09.024|
|Deposited On:||20 Aug 2012 12:26|
|Last Modified:||26 Aug 2012 12:58|
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