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Polycaprolactone-based scaffold plus recombinant human bone morphogenetic protein (rhBMP-2) in an ovine model of anterior spinal fusion

Yong, Mostyn, Domingos, Marco, Melchels, Ferry P.W., Hutmacher, Dietmar W., Bartolo, Paulo J., Labrom, Robert D., Askin, Geoffrey N., & Adam, Clayton J. (2012) Polycaprolactone-based scaffold plus recombinant human bone morphogenetic protein (rhBMP-2) in an ovine model of anterior spinal fusion. In Spine Society of Australia 23rd Annual Scientific Meeting, 27-29 April 2012, The Westin, Sydney, NSW.

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      Abstract

      Synthetic scaffolds combined with growth factors have the potential to replace allograft or autograft as a graft material for spinal interbody fusion. Such tissue engineering approaches may be useful in Adolescent Idiopathic Scoliosis (AIS) surgery, however there are no studies to date examining the use of such biodegradable implants in combination with biologics in a thoracic spine model. This in vivo study examines the use of biodegradable polycaprolactone (PCL) based scaffolds with rhBMP-2 as a bone graft substitute in a sheep thoracic fusion model, where an anterior approach is used to simulate minimally invasive surgical deformity correction in the setting of AIS.

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      ID Code: 53235
      Item Type: Conference Paper
      Keywords: biodegradable scaffold, thoracic fusion, in vivo sheep , polycaprolactone scaffold, rhBMP-2
      Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
      Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Medical Devices (090304)
      Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Orthopaedics (110314)
      Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
      Current > QUT Faculties and Divisions > Faculty of Health
      Current > Institutes > Institute of Health and Biomedical Innovation
      Current > QUT Faculties and Divisions > Science & Engineering Faculty
      Copyright Owner: Copyright 2012 The Authors
      Deposited On: 22 Aug 2012 08:51
      Last Modified: 04 Sep 2012 04:55

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