Vertical Inhibition of the PI3K/Akt/mTOR Pathway for the Treatment of Osteoarthritis

Chen, Jiezhong, Crawford, Ross, & Xiao, Yin (2013) Vertical Inhibition of the PI3K/Akt/mTOR Pathway for the Treatment of Osteoarthritis. Journal of Cellular Biochemistry, 114(2), pp. 245-249.

View at publisher


Osteoarthritis is characterized by degenerative alterations of articular cartilage including both the degradation of extracellular matrix and the death of chondrocytes. The PI3K/Akt pathway has been demonstrated to involve in both processes. Inhibition of its downstream target NF-kB reduces the degradation of extracellular matrix via decreased production of matrix metalloproteinases while inhibition of mTOR increased autophagy to reduce chondrocyte death. However, mTOR feedback inhibits the activity of the PI3K/Akt pathway and inhibition of mTOR could result in increased activity of the PI3K/Akt/NF-kB pathway. We proposed that the use of dual inhibitors of PI3K and mTOR could be a promising approach to more efficiently inhibit the PI3K/Akt pathway than rapamycin or PI3K inhibitor alone and produce better treatment outcome.

Impact and interest:

23 citations in Scopus
Search Google Scholar™
19 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 53256
Item Type: Journal Article
Refereed: Yes
Keywords: Osteoarthritis, Extracellular matrix metalloproteinases, Autophagy, PI3K/Akt pathway
DOI: 10.1002/jcb.24362
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 John Wiley & Sons, Inc.
Deposited On: 09 Jan 2013 23:04
Last Modified: 12 Jun 2013 15:07

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page