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Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis

Lee, Joseph C., Fraser, John F., Barnett, Adrian G., Johnson, Leslie P., Wilson, Melinda G., McHenry, Catherine M., Walters, Darren L., Warnholtz, Christopher R., & Khafagi, Frederick A. (2012) Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis. Journal of Nuclear Cardiology, 19(3), pp. 474-481.

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Abstract

Objectives

This prospective study investigated the effects of caffeine ingestion on the extent of adenosine-induced perfusion abnormalities during myocardial perfusion imaging (MPI).

Methods

Thirty patients with inducible perfusion abnormalities on standard (caffeine-abstinent) adenosine MPI underwent repeat testing with supplementary coffee intake. Baseline and test MPIs were assessed for stress percent defect, rest percent defect, and percent defect reversibility. Plasma levels of caffeine and metabolites were assessed on both occasions and correlated with MPI findings.

Results

Despite significant increases in caffeine [mean difference 3,106 μg/L (95% CI 2,460 to 3,752 μg/L; P < .001)] and metabolite concentrations over a wide range, there was no statistically significant change in stress percent defect and percent defect reversibility between the baseline and test scans. The increase in caffeine concentration between the baseline and the test phases did not affect percent defect reversibility (average change −0.003 for every 100 μg/L increase; 95% CI −0.17 to 0.16; P = .97).

Conclusion

There was no significant relationship between the extent of adenosine-induced coronary flow heterogeneity and the serum concentration of caffeine or its principal metabolites. Hence, the stringent requirements for prolonged abstinence from caffeine before adenosine MPI—based on limited studies—appear ill-founded.

Impact and interest:

3 citations in Scopus
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2 citations in Web of Science®

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85 since deposited on 30 Aug 2012
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ID Code: 53386
Item Type: Journal Article
Keywords: Myocardial perfusion imaging, adenosine, caffeine
DOI: 10.1007/s12350-012-9517-x
ISSN: 1532-6551
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CARDIOVASCULAR MEDICINE AND HAEMATOLOGY (110200) > Cardiology (incl. Cardiovascular Diseases) (110201)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2012 Springer.
Deposited On: 30 Aug 2012 17:25
Last Modified: 31 Aug 2012 14:24

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