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Silk fibroin in ocular surface reconstruction : what is its potential as a biomaterial in ophthalmics?

Harkin, Damien G. & Chirila, Traian (2012) Silk fibroin in ocular surface reconstruction : what is its potential as a biomaterial in ophthalmics? Frontiers in Medicinal Chemistry, 4(17), pp. 2145-2147.

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    Abstract

    Hardly a month goes by within the scientific literature without some new material “X” being reported as a suitable material on which to grow cell type “Y”, for the potential purpose of treating disease “Z”. Thus when fibroin, a protein found in silk, was first proposed as a biomaterial for cell growth [1] it joined a long list of other materials of both natural as well as synthetic origin. Nevertheless, in the second decade of the Asian Century it is perhaps befitting that a material of so much importance to the continent’s cultural and economic history, should become the focus of cutting-edge biomedical research. Sentiments aside, however, silk fibroin possesses quite a unique combination of properties which make it a promising candidate for repairing the eye and especially for treating damage to the cornea, the transparent window at the front of the eye.

    Impact and interest:

    2 citations in Scopus
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    1 citations in Web of Science®

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    ID Code: 53796
    Item Type: Journal Article
    Additional Information: 12-month embargo after published
    Keywords: Silk fibroin, Tissue engineering, Regenerative medicine, Biomaterials, Eye disease, Corneal transplantation
    DOI: 10.4155/fmc.12.155
    ISSN: 1875-5763
    Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
    Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Ophthalmology (111301)
    Divisions: Current > Schools > School of Biomedical Sciences
    Current > QUT Faculties and Divisions > Faculty of Health
    Current > Institutes > Institute of Health and Biomedical Innovation
    Copyright Owner: Copyright 2012 Bentham Science Publishers
    Deposited On: 24 Sep 2012 09:11
    Last Modified: 11 Feb 2013 17:13

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