Preparation, characterization, and in vitro bioactivity of nagelschmidtite bioceramics

Wu, Chengtie, Fan, Wei, Chang, Jiang, Zhang, Meili, & Xiao, Yin (2013) Preparation, characterization, and in vitro bioactivity of nagelschmidtite bioceramics. Journal of the American Ceramic Society, 96(3), pp. 928-934.

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The aim of this study is to prepare Ca, P and Si-containing ternary oxide nagelschmidtite (NAGEL, Ca7Si2P2O16) bioceramics and explore their in vitro bioactivity for potential bone tissue regeneration. We prepared dense NAGEL ceramics through high-temperature sintering of NAGEL ceramic powders. The apatite-mineralization ability, dissolution rate, and human osteoblast response (including cytotoxicity analysis, attachment, morphology, proliferation, and bone-related gene expression) to NAGEL ceramics have been systematically studied by comparing with conventional β-tricalcium phosphate (β-TCP) ceramics. The results showed that NAGEL ceramics possessed more obvious apatite mineralization and dissolution (degradation) and stimulated bone-related gene expression (OCN and OPN) of osteoblasts than β-TCP ceramics. NAGEL ceramics also showed no significant cytotoxicity. NAGEL ceramics supported osteoblast attachment, proliferation, and osteogenic gene expression, with a comparable cell proliferation activity with β-TCP ceramics. These results indicate that novel NAGEL bioceramics with the specific composition of Ca7Si2P2O16, are a promising biomaterial for bone tissue regeneration application.

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ID Code: 53872
Item Type: Journal Article
Refereed: Yes
Keywords: In Vitro bioactivity, NAGEL ceramics, b-TCP ceramics, Bone-related gene expression, Osteoblasts
DOI: 10.1111/jace.12059
ISSN: 1551-2916
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 26 Mar 2013 23:11
Last Modified: 12 Jun 2013 15:11

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