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Early inflammatory and myogenic responses to resistance exercise in the elderly

Mathers, Jessica , Farnfield, Michelle , Garnham, Andrew , Caldow, Marissa , Cameron-Smith, David , & Peake, Jonathan (2012) Early inflammatory and myogenic responses to resistance exercise in the elderly. Muscle & Nerve, 46(3), pp. 407-412.

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Abstract

Introduction and Methods: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). Results: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. Conclusions: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury

Impact and interest:

2 citations in Scopus
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2 citations in Web of Science®

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ID Code: 53922
Item Type: Journal Article
Additional URLs:
Keywords: exercise, aging, muscle damage, inflammation, oestrogen
DOI: 10.1002/mus.23317
ISSN: 1097-4598 (online) 0148-639X (print)
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Geriatrics and Gerontology (110308)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 John Wiley & Sons, Inc.
Deposited On: 02 Oct 2012 14:15
Last Modified: 13 Jun 2013 01:12

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