Expression and distribution of cell-surface proteoglycans in the normal Lewis rat molar periodontium
Worapamorn, W., Li, H., Zac, P., Xiao, Y., Young, WG, & Bartold, P. M. (2000) Expression and distribution of cell-surface proteoglycans in the normal Lewis rat molar periodontium. Journal of Periodontal Research, 35(4), pp. 214-224.
Cell-surface proteoglycans participate in several biological functions such as cell cell and cell-matrix interactions, cell adhesion, the binding to various growth factors as co-receptors and repair. To understand better the expression and distribution of cell-surface proteoglycans in the periodontal tissues, an immunohistochemical evaluation of the normal Lewis rat molar periodontium using panels of antibodies for syndecan-1, -2, -4, glypican and betaglycan was carried out. Our results demonstrated the expression and distribution of all proteoglycans in the suprabasal gingival epithelium, soft and hard connective tissues. Both cellular and matrix localization was evident within the various periodontal compartments. The presence of these cell-surface proteoglycans indicates the potential for roles in the process of tissue homeostasis, repair or regeneration in periodontium of which each function requires further study.
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|Item Type:||Journal Article|
|Keywords:||periodontium, syndecan-1, syndecan-2, syndecan-4, glypican, betaglycan|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)|
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > DENTISTRY (110500)
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Deposited On:||10 Oct 2012 11:35|
|Last Modified:||10 Oct 2012 11:35|
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