Growth-hormone-stimulated dentinogenesis in Lewis dwarf rat molars

Young, William G, Li, Huika, Xiao, Yin, Waters, Michael John, & Bartold, P.Mark (2001) Growth-hormone-stimulated dentinogenesis in Lewis dwarf rat molars. Journal of Dental Research, 80(8), pp. 1742-1747.

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In dentinogenesis, certain growth factors, matrix proteoglycans, and proteins are directly or indirectly dependent on growth hormone. The hypothesis that growth hormone up-regulates the expression of enzymes, sialoproteins, and other extracellular matrix proteins implicated in the formation and mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with growth hormone over 5 days. The molar teeth were processed for immunohistochemical demonstration of bone-alkaline phosphatase, bone morphogenetic proteins-2 and -4, osteocalcin, osteopontin, bone sialoprotein, and E11 protein. Odontoblasts responded to growth hormone by more cells expressing bone morphogenetic protein, alkaline phosphatase, osteocalcin, and osteopontin. No changes were found in bone sialoprotein or E11 protein expression. Thus, growth hormone may stimulate odontoblasts to express several growth factors and matrix proteins associated with dentin matrix biosynthesis in mature rat molars.

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ID Code: 54056
Item Type: Journal Article
Refereed: Yes
Keywords: growth hormone, dentin matrix, teeth
DOI: 10.1177/00220345010800081201
ISSN: 1544-0591 (online) 0022-0345 (print)
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 Sage Publications, Inc.
Deposited On: 10 Oct 2012 02:11
Last Modified: 16 Jul 2017 20:03

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