Fabrication of a corneal-limbal tissue substitute using silk fibroin
Bray, Laura J., George, Karina A., Suzuki, Shuko, Chirila, Traian V., & Harkin, Damien G. (2012) Fabrication of a corneal-limbal tissue substitute using silk fibroin. In Wright, Bernice & Connon, Che (Eds.) Methods in Regeneration of the Cornea. Human Press Ltd.. (In Press)
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Fibroin extracted from silkworm cocoon silk provides an intriguing and potentially important biomaterial for corneal reconstruction. In the present chapter we outline our methods for producing a composite of two fibroin-based materials that supports the co-cultivation of human limbal epithelial (HLE) cells and human limbal stromal (HLS) cells. The resulting tissue substitute consists of a stratified epithelium overlying a three-dimensional arrangement of extracellular matrix components (principally ‘degummed’ fibroin fibers) and mesenchymal stromal cells. This tissue substitute is currently being evaluated as a tool for reconstructing the corneal limbus and corneal epithelium.
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|Item Type:||Book Chapter|
|Keywords:||Silk fibroin, Corneal limbus, Corneal epithelium, Limbal epithelium, Mesenchymal stromal cells|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)|
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Ophthalmology (111301)
|Divisions:||Current > Schools > School of Biomedical Sciences|
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2012 Please consult the authors.|
|Deposited On:||15 Oct 2012 17:44|
|Last Modified:||06 Feb 2013 12:38|
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