Corneal sensitivity is related to established measures of diabetic peripheral neuropathy
Pritchard, Nicola, Edwards, Katie, Vagenas, Dimitrios, Russell, Anthony, Malik, Rayaz A., & Efron, Nathan (2012) Corneal sensitivity is related to established measures of diabetic peripheral neuropathy. Clinical and Experimental Optometry, 95(3), pp. 355-361.
Purpose: The objective was to investigate the association between corneal sensitivity and established measures of diabetic peripheral neuropathy (DPN).
Methods: Corneal sensitivity was measured in 93 individuals with diabetes, 146 diabetic individuals without neuropathy and 61 control individuals without diabetes or neuropathy using a non-contact corneal aesthesiometer at the baseline visit of a five-year longitudinal natural history study of DPN. The correlation between corneal sensitivity and established measures of neuropathy was estimated and multi-dimensional scaling was used to represent similarities and dissimilarities between variables.
Results: The corneal sensitivity threshold was significantly correlated with a majority of established measures of DPN. Correlation coefficients ranged from -0.32 to 0.26. Using multi-dimensional scaling, non-contact corneal aesthesiometry was closer to the neuropathy disability score, diabetic neuropathy symptom score and Neuropad and most dissimilar to electrophysiological parameters and quantitative sensory testing.
Conclusion: Corneal sensitivity, although not strongly related, is associated with other functional measures of DPN and might provide a useful adjunct in identifying functional loss of small nerve fibre integrity.
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|Item Type:||Journal Article|
|Additional Information:||This special issue on Diabetes and the Eye has been co-ordinated by Professor Nathan Efron and Associate Professor Erica Fletcher|
|Keywords:||aesthesiometry, cornea, corneal sensitivity, diabetes, diabetic neuropathy, non-contact corneal aesthesiometry|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Deposited On:||15 Oct 2012 22:56|
|Last Modified:||18 Oct 2012 00:57|
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