Corneal sensitivity is related to established measures of diabetic peripheral neuropathy

Pritchard, Nicola, Edwards, Katie, Vagenas, Dimitrios, Russell, Anthony, Malik, Rayaz A., & Efron, Nathan (2012) Corneal sensitivity is related to established measures of diabetic peripheral neuropathy. Clinical and Experimental Optometry, 95(3), pp. 355-361.

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Purpose:  The objective was to investigate the association between corneal sensitivity and established measures of diabetic peripheral neuropathy (DPN).

Methods:  Corneal sensitivity was measured in 93 individuals with diabetes, 146 diabetic individuals without neuropathy and 61 control individuals without diabetes or neuropathy using a non-contact corneal aesthesiometer at the baseline visit of a five-year longitudinal natural history study of DPN. The correlation between corneal sensitivity and established measures of neuropathy was estimated and multi-dimensional scaling was used to represent similarities and dissimilarities between variables.

Results:  The corneal sensitivity threshold was significantly correlated with a majority of established measures of DPN. Correlation coefficients ranged from -0.32 to 0.26. Using multi-dimensional scaling, non-contact corneal aesthesiometry was closer to the neuropathy disability score, diabetic neuropathy symptom score and Neuropad and most dissimilar to electrophysiological parameters and quantitative sensory testing.

Conclusion:  Corneal sensitivity, although not strongly related, is associated with other functional measures of DPN and might provide a useful adjunct in identifying functional loss of small nerve fibre integrity.

Impact and interest:

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7 citations in Web of Science®

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ID Code: 54179
Item Type: Journal Article
Refereed: Yes
Additional Information: This special issue on Diabetes and the Eye has been co-ordinated by Professor Nathan Efron and Associate Professor Erica Fletcher
Keywords: aesthesiometry, cornea, corneal sensitivity, diabetes, diabetic neuropathy, non-contact corneal aesthesiometry
DOI: 10.1111/j.1444-0938.2012.00729.x
ISSN: 0816-4622
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 15 Oct 2012 22:56
Last Modified: 18 Oct 2012 00:57

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