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Omega-3 polyunsaturated fatty acids in the treatment of kidney disease

Fassett, Robert, Gobe, Glenda, Peake, Jonathan, & Coombes, Jeff S. (2010) Omega-3 polyunsaturated fatty acids in the treatment of kidney disease. American Journal of Kidney Diseases, 56(4), pp. 728-742.

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Abstract

After more than 25 years of published investigation, including randomized controlled trials, the role of omega-3 polyunsaturated fatty acids in the treatment of kidney disease remains unclear. In vitro and in vivo experimental studies support the efficacy of omega-3 polyunsaturated fatty acids on inflammatory pathways involved with the progression of kidney disease. Clinical investigations have focused predominantly on immunoglobulin A (IgA) nephropathy. More recently, lupus nephritis, polycystic kidney disease, and other glomerular diseases have been investigated. Clinical trials have shown conflicting results for the efficacy of omega-3 polyunsaturated fatty acids in IgA nephropathy, which may relate to varying doses, proportions of eicosapentaenoic acid and docosahexaenoic acid, duration of therapy, and sample size of the study populations. Meta-analyses of clinical trials using omega-3 polyunsaturated fatty acids in IgA nephropathy have been limited by the quality of available studies. However, guidelines suggest that omega-3 polyunsaturated fatty acids should be considered in progressive IgA nephropathy. Omega-3 polyunsaturated fatty acids decrease blood pressure, a known accelerant of kidney disease progression. Well-designed, adequately powered, randomized, controlled clinical trials are required to further investigate the potential benefits of omega-3 polyunsaturated fatty acids on the progression of kidney disease and patient survival.

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37 citations in Scopus
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30 citations in Web of Science®

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ID Code: 54298
Item Type: Journal Article
Keywords: fish oil, kidney disease, inflammation, clinical trial
DOI: 10.1053/j.ajkd.2010.03.009
ISSN: 1523-6838
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Nephrology and Urology (110312)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100) > Nutritional Physiology (111103)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 25 Oct 2012 13:19
Last Modified: 26 Oct 2012 11:40

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