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More light at the end of the tunnel – apixaban in atrial fibrillation

Doggrell, Sheila A. (2012) More light at the end of the tunnel – apixaban in atrial fibrillation. Expert Opinion in Investigational Drugs, 21(8), pp. 1235-1239.

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Abstract

Introduction: Subjects with atrial fibrillation are at risk of thromboembolic events. The vitamin K antagonists (e.g., warfarin) are useful at preventing coagulation in atrial fibrillation, but are difficult to use. One of the FXa inhibitors, oral apixaban, has been tested as an anticoagulant in atrial fibrillation.

Areas covered: In ARISTOTLE (Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation) apixaban was compared to warfarin in subjects with atrial fibrillation, and shown to cause a lower rate of stroke or systemic embolism and of major bleeding, than warfarin. In the AVERROES (Apixaban versus acetylsalicylic acid [ASA] to prevent stroke in atrial fibrillations patients who have failed or are unsuitable for vitamin K antagonist treatment) trial, stroke or systemic embolism occurred less often with apixaban than aspirin, whereas the occurrence of major bleeding was similar in the groups.

Expert opinion: Apixaban is much easier for subjects with atrial fibrillation to use than warfarin, as it does not require regular monitoring by a health professional, with dosage adjustment. In addition to replacing warfarin in subjects with atrial fibrillation who are unable or not prepared to use warfarin, apixaban has the potential to replace warfarin more widely in the prevention of thromboembolism in subjects with atrial fibrillation.

Impact and interest:

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ID Code: 54567
Item Type: Review
Keywords: apixaban, atrial fibrillation, atrial fibrillation, ischaemic and haemorrhagic stroke, major bleeding, thromboembolic events, warfarin
DOI: 10.1517/13543784.2012.696611
ISSN: 1744-7658 (online) 1354-3784 (print)
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2012 Informa UK Limited
Deposited On: 05 Nov 2012 09:54
Last Modified: 07 Nov 2014 15:51

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