The post-illumination pupil response of melanopsin expressing intrinsically photosensitive retinal ganglion cells in diabetes

Feigl, Beatrix, Zele, Andrew J., Fader, Samantha M., Howes, Annelisa N., Hughes, Catherine E., Jones, Kris A., & Jones, Rawlyn (2012) The post-illumination pupil response of melanopsin expressing intrinsically photosensitive retinal ganglion cells in diabetes. Acta Ophthalmologica, 90(3), e230-e234.

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This study investigates the clinical utility of the melanopsin expressing intrinsically photosensitive retinal ganglion cell (ipRGC) controlled post-illumination pupil response (PIPR) as a novel technique for documenting inner retinal function in patients with Type II diabetes without diabetic retinopathy.


The post-illumination pupil response (PIPR) was measured in seven patients with Type II diabetes, normal retinal nerve fiber thickness and no diabetic retinopathy. A 488 nm and 610 nm, 7.15º diameter stimulus was presented in Maxwellian view to the right eye and the left consensual pupil light reflex was recorded.


The group data for the blue PIPR (488 nm) identified a trend of reduced ipRGC function in patients with diabetes with no retinopathy. The transient pupil constriction was lower on average in the diabetic group. The relationship between duration of diabetes and the blue PIPR amplitude was linear, suggesting that ipRGC function decreases with increasing diabetes duration.


This is the first report to show that the ipRGC controlled post-illumination pupil response may have clinical applications as a non-invasive technique for determining progression of inner neuroretinal changes in patients with diabetes before they are ophthalmoscopically or anatomically evident. The lower transient pupil constriction amplitude indicates that outer retinal photoreceptor inputs to the pupil light reflex may also be affected in diabetes.

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28 citations in Scopus
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17 citations in Web of Science®

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97 since deposited on 13 Nov 2012
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ID Code: 54741
Item Type: Journal Article
Refereed: Yes
Funders: ARC
Keywords: pupil, diabetes, melanopsin, intrinsically photosensitive retinal ganglion cells, post-illumination pupil response
DOI: 10.1111/j.1755-3768.2011.02226.x
ISSN: 1755-375X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Wiley-Blackwell Publishing
Deposited On: 13 Nov 2012 01:01
Last Modified: 19 May 2015 02:31

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