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Biochemical profiling of proteins and metabolites in wound exudate from chronic wound environments

Broszczak, Daniel, Stupar, Dario, Compay, Arnulf Lloyd Lucero, Sharma, Masti Venugopal Srihari, Parker, Tony J., Shooter, Gary K., Upton, Zee, & Fernandez, Melissa Laura (2012) Biochemical profiling of proteins and metabolites in wound exudate from chronic wound environments. Wound Practice and Research, 20(2), pp. 62-72.

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    Abstract

    The lack of fundamental knowledge on the biological processes associated with wound healing represents a significant challenge. Understanding the biochemical changes that occur within a chronic wound could provide insights into the wound environment and enable more effective wound management. We report on the stability of wound fluid samples under various conditions and describe a high-throughput approach to investigate the altered biochemical state within wound samples collected from various types of chronic, ulcerated wounds. Furthermore, we discuss the viability of this approach in the early stages of wound sample protein and metabolite profiling and subsequent biomarker discovery. This approach will facilitate the detection of factors that may correlate with wound severity and/or could be used to monitor the response to a particular treatment.

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    ID Code: 54830
    Item Type: Journal Article
    Keywords: Wound, Biomarker, Diagnostic, Proteomic, Metabolomic, Chronic Wound, Skin
    ISSN: 1837-6304
    Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Amino Acids and Metabolites (110101)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry - Proteins and Peptides (incl. Medical Proteomics) (110106)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Clinical Chemistry (diagnostics) (110302)
    Divisions: Current > Schools > School of Biomedical Sciences
    Current > QUT Faculties and Divisions > Faculty of Health
    Current > Institutes > Institute of Health and Biomedical Innovation
    Copyright Owner: Copyright 2012 Cambridge Publishing
    Deposited On: 19 Nov 2012 09:15
    Last Modified: 23 Nov 2012 03:16

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