Plant-made vaccines for humans and animals

Rybicki, E. P. (2010) Plant-made vaccines for humans and animals. Plant Biotechnology Journal, 8(5), pp. 620-637.

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Summary: The concept of using plants to produce high-value pharmaceuticals such as vaccines is 20 years old this year and is only now on the brink of realisation as an established technology. The original reliance on transgenic plants has largely given way to transient expression; proofs of concept for human and animal vaccines and of efficacy for animal vaccines have been established; several plant-produced vaccines have been through Phase I clinical trials in humans and more are scheduled; regulatory requirements are more clear than ever, and more facilities exist for manufacture of clinic-grade materials. The original concept of cheap edible vaccines has given way to a realisation that formulated products are required, which may well be injectable. The technology has proven its worth as a means of cheap, easily scalable production of materials: it now needs to find its niche in competition with established technologies. The realised achievements in the field as well as promising new developments will be reviewed, such as rapid-response vaccines for emerging viruses with pandemic potential and bioterror agents. © 2010 The Author. Journal compilation © 2010 Blackwell Publishing Ltd.

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159 citations in Scopus
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129 citations in Web of Science®

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ID Code: 54928
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 45 Export Date: 12 November 2012 Source: Scopus
Keywords: Pharmaceutical, Plant, Plant biotechnology, Transgenic plant, Transient expression, Vaccine
DOI: 10.1111/j.1467-7652.2010.00507.x
Deposited On: 20 Nov 2012 02:46
Last Modified: 20 Nov 2012 02:57

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