Evidence of ancient papillomavirus recombination

Varsani, A., van der Walt, E., Heath, L., Rybicki, E. P., Williamson, A. L., & Martin, D. P. (2006) Evidence of ancient papillomavirus recombination. Journal of General Virology, 87(9), pp. 2527-2531.

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An open question amongst papillomavirus taxonomists is whether recombination has featured in the evolutionary history of these viruses. Since the onset of the global AIDS epidemic, the question is somewhat less academic, because immune-compromised human immunodeficiency virus patients are often co-infected with extraordinarily diverse mixtures of human papillomavirus (HPV) types. It is expected that these conditions may facilitate the emergence of HPV recombinants, some of which might have novel pathogenic properties. Here, a range of rigorous analyses is applied to full-genome sequences of papillomaviruses to provide convincing statistical and phylogenetic evidence that evolutionarily relevant papillomavirus recombination can occur. © 2006 SGM.

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46 citations in Scopus
44 citations in Web of Science®
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ID Code: 54934
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 28
Export Date: 12 November 2012
Source: Scopus
DOI: 10.1099/vir.0.81917-0
Deposited On: 20 Nov 2012 02:46
Last Modified: 29 May 2013 16:53

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