The evolutionary value of recombination is constrained by genome modularity

Martin, D. P., van der Walt, E., Posada, D., & Rybicki, E. P. (2005) The evolutionary value of recombination is constrained by genome modularity. PLoS Genetics, 1(4).

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Genetic recombination is a fundamental evolutionary mechanism promoting biological adaptation. Using engineered recombinants of the small single-stranded DNA plant virus, Maize streak virus (MSV), we experimentally demonstrate that fragments of genetic material only function optimally if they reside within genomes similar to those in which they evolved. The degree of similarity necessary for optimal functionality is correlated with the complexity of intragenomic interaction networks within which genome fragments must function. There is a striking correlation between our experimental results and the types of MSV recombinants that are detectable in nature, indicating that obligatory maintenance of intragenome interaction networks strongly constrains the evolutionary value of recombination for this virus and probably for genomes in general.

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ID Code: 54936
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 26 Export Date: 12 November 2012 Source: Scopus
DOI: 10.1371/journal.pgen.0010051
Deposited On: 20 Nov 2012 02:46
Last Modified: 20 Nov 2012 02:57

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