Strategies for the prevention of cervical cancer by human papillomavirus vaccination

Williamson, A. L., Passmore, J. A., & Rybicki, E. P. (2005) Strategies for the prevention of cervical cancer by human papillomavirus vaccination. Best Practice and Research: Clinical Obstetrics and Gynaecology, 19(4 SPEC), pp. 531-544.

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As cervical cancer is causally associated with 14 high-risk types of human papillomavirus (HPV), a successful HPV vaccine will have a major impact on this disease. Although some persistent HPV infections progress to cervical cancer, host immunity is generally able to clear most HPV infections. Both cell-mediated and antibody responses have been implicated in influencing the susceptibility, persistence or clearance of genital HPV infection. There have been two clinical trials that show that vaccines based on virus-like particles (VLPs) made from the major capsid protein, L1, are able to type specifically protect against cervical intra-epithelial neoplasia and infection. However, there is no evidence that even a mixed VLP vaccine will protect against types not included in the vaccine, and a major challenge that remains is how to engineer protection across a broader spectrum of viruses. Strategies for production of HPV vaccines using different vaccine vectors and different production systems are also reviewed. © 2005 Elsevier Ltd. All rights reserved.

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ID Code: 54953
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 14
Export Date: 12 November 2012
Source: Scopus
Keywords: Cervical cancer vaccines, Human papillomavirus vaccines, Virus-like particles
DOI: 10.1016/j.bpobgyn.2005.02.006
Deposited On: 20 Nov 2012 02:46
Last Modified: 10 Dec 2012 05:01

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