Vaccination strategies for the prevention of cervical cancer

Maclean, J., Rybicki, E. P., & Williamson, A. L. (2005) Vaccination strategies for the prevention of cervical cancer. Expert Review of Anticancer Therapy, 5(1), pp. 97-107.

View at publisher

Abstract

Infection with high-risk human papillomaviruses (HPVs) is an essential step in the multistep process leading to cervical cancer. There are approximately 120 different types of HPV identified: of these, 18 are high-risk types associated with cervical cancer, with HPV-16 being the dominant type in most parts of the world. The major capsid protein of papillomavirus, produced in a number of expression systems, self assembles to form virus-like particles. Virus-like particles are the basis of the first generation of HPV vaccines presently being tested in clinical trials. Virus-like particles are highly immunogenic and afford protection from infection both in animal models and in Phase IIb clinical trials. A number of Phase III trials are in progress to determine if the vaccine will protect against cervical disease and, in some cases, genital warts. However, it is predicted that these vaccines will be too expensive for the developing world, where they are desperately needed. Another problem is that they will be type specific. Novel approaches to the production of virus-like particles in plants, second-generation vaccine approaches including viral and bacterial vaccine vectors and DNA vaccines, as well as different routes of immunization, are also reviewed. © 2005 Future Drugs Ltd.

Impact and interest:

15 citations in Scopus
Search Google Scholar™
12 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 54954
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 14
Export Date: 12 November 2012
Source: Scopus
Keywords: Cervical cancer, Papillomavirus, Vaccine, Virus-like particles
DOI: 10.1586/14737140.5.1.xxx
Deposited On: 20 Nov 2012 02:46
Last Modified: 29 May 2013 16:53

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page