Human papillomavirus vaccines in plants

Giorgi, C., Franconi, R., & Rybicki, E. P. (2010) Human papillomavirus vaccines in plants. Expert Review of Vaccines, 9(8), pp. 913-924.

View at publisher


Human papillomaviruses are the etiological agents of cervical cancer, one of the two most prevalent cancers in women in developing countries. Currently available prophylactic vaccines are based on the L1 major capsid protein, which forms virus-like particles when expressed in yeast and insect cell lines. Despite their recognized efficacy, there are significant shortcomings: the vaccines are expensive, include only two oncogenic virus types, are delivered via intramuscular injection and require a cold chain. Plant expression systems may provide ways of overcoming some of these problems, in particular the expense. In this article, we report recent promising advances in the production of prophylactic and therapeutic vaccines against human papillomavirus by expression of the relevant antigens in plants, and discuss future prospects for the use of such vaccines. © 2010 Expert Reviews Ltd.

Impact and interest:

26 citations in Scopus
Search Google Scholar™
22 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 54967
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 9
Export Date: 12 November 2012
Source: Scopus
Keywords: cancer vaccine, cervical carcinoma, human papillomavirus, human papillomavirus infection, immunotherapy, plant-produced vaccine, prophylaxis, virus-like particles
DOI: 10.1586/erv.10.84
Deposited On: 20 Nov 2012 02:46
Last Modified: 20 Nov 2012 02:57

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page