Immunogenicity of an HPV-16 L2 DNA vaccine
Hitzeroth, I. I., Passmore, J. A. S., Shephard, E., Stewart, D., Müller, M., Williamson, A. L., Rybicki, E. P., & Kast, W. M. (2009) Immunogenicity of an HPV-16 L2 DNA vaccine. Vaccine, 27(46), pp. 6432-6434.
The ability to elicit cross-neutralizing antibodies makes human papillomavirus (HPV) L2 capsid protein a possible HPV vaccine. We examined and compared the humoral response of mice immunized with a HPV-16 L2 DNA vaccine or with HPV-16 L2 protein. The L2 DNA vaccine elicited a non-neutralizing antibody response unlike the L2 protein. L2 DNA vaccination suppressed the growth of L2-expressing C3 tumor cells, which is a T cell mediated effect, demonstrating that the lack of non-neutralizing antibody induction by L2 DNA was not caused by lack of T cell immunogenicity of the construct. © 2009 Elsevier Ltd. All rights reserved.
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|Item Type:||Journal Article|
|Additional Information:||Cited By (since 1996): 4
Export Date: 12 November 2012
|Keywords:||1.2 protein, DNA vaccine, Human papillomavirus, Immunogenicity|
|Deposited On:||20 Nov 2012 02:46|
|Last Modified:||29 May 2013 16:54|
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