Immunogenicity of an HPV-16 L2 DNA vaccine

Hitzeroth, I. I., Passmore, J. A. S., Shephard, E., Stewart, D., Müller, M., Williamson, A. L., Rybicki, E. P., & Kast, W. M. (2009) Immunogenicity of an HPV-16 L2 DNA vaccine. Vaccine, 27(46), pp. 6432-6434.

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Abstract

The ability to elicit cross-neutralizing antibodies makes human papillomavirus (HPV) L2 capsid protein a possible HPV vaccine. We examined and compared the humoral response of mice immunized with a HPV-16 L2 DNA vaccine or with HPV-16 L2 protein. The L2 DNA vaccine elicited a non-neutralizing antibody response unlike the L2 protein. L2 DNA vaccination suppressed the growth of L2-expressing C3 tumor cells, which is a T cell mediated effect, demonstrating that the lack of non-neutralizing antibody induction by L2 DNA was not caused by lack of T cell immunogenicity of the construct. © 2009 Elsevier Ltd. All rights reserved.

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10 citations in Scopus
10 citations in Web of Science®
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ID Code: 54983
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 4
Export Date: 12 November 2012
Source: Scopus
Keywords: 1.2 protein, DNA vaccine, Human papillomavirus, Immunogenicity
DOI: 10.1016/j.vaccine.2009.06.015
Deposited On: 20 Nov 2012 02:46
Last Modified: 29 May 2013 16:54

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