Vaccine farming in Cape Town

Rybicki, E. P., Williamson, A. L., Meyers, A., & Hitzeroth, I. I. (2011) Vaccine farming in Cape Town. Human Vaccines, 7(3), pp. 339-348.

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The review details the development of the Subunit Vaccine Group at the University of Cape Town, from its beginnings as a plant virology laboratory in the 1980s. The investigation and development of Human papillomavirus (HPV) and Human immunodeficiency vaccine candidates are covered in detail, with an emphasis on how this work allowed the evolution of a systematic approach to the optimisation of expression of these and other proteins especially in plants, but also in insect cell culture. We discuss various insights gained during our work, such as approaches to codon optimisation, use of different vector systems and plant hosts, intracellular targetting and gene modification. The future prospects for both our work and for the field of plant-made vaccines in general, are discussed. © 2011 Landes Bioscience.

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7 citations in Scopus
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5 citations in Web of Science®

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ID Code: 54988
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996): 2 Export Date: 12 November 2012 Source: Scopus
Keywords: Biopharming, Geminivirus, HIV, HPV, Papillomavirus, Plants, Vaccines
DOI: 10.4161/hv.7.3.14263
Deposited On: 20 Nov 2012 02:46
Last Modified: 29 May 2013 16:54

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