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KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence

Morris, Charles P., Baune, Bernhard T., Domschke, Katharina, Arolt, Volker, Swagell, Christopher D., Hughes, Ian P., Lawford, Bruce R., Young, Ross McD, & Voisey, Joanne (2012) KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. Disease Markers, 33(4), pp. 163-70.

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Abstract

KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level. Major depression was also associated with rs2273816 but only at the allele level. Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders.

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ID Code: 55214
Item Type: Journal Article
Additional Information: Morris, Charles P Baune, Bernhard T Domschke, Katharina Arolt, Volker Swagell, Christopher D Hughes, Ian P Lawford, Bruce R McD Young, Ross Voisey, Joanne Netherlands Disease markers Dis Markers. 2012 Jan 1;33(4):163-70. doi: 10.3233/DMA-2012-0921.
Keywords: KPNA3, genetics, schizophrenia, polymorphism, psychiatric disorder
DOI: 10.3233/DMA-2012-0921
ISSN: 1875-8630
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > AGRICULTURAL AND VETERINARY SCIENCES (070000)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 I.O.S Press
Deposited On: 30 Nov 2012 09:11
Last Modified: 24 Mar 2013 19:53

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