Paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology

Tse, Brian W.C., Scott, Kieran F., & Russell, Pamela J. (2012) Paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology. Prostate Cancer, 2012, pp. 1-8.

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Tumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology including prostate cancer (PCa). On the one hand, there is evidence that it stimulates tumour angiogenesis, is involved in the initiation of PCa from an androgen-dependent to a castrate resistant state, plays a role in epithelial to mesenchymal plasiticity, and may contribute to the aberrant regulation of eicosanoid pathways. On the other hand, TNF has also been reported to inhibit neovascularisation, induce apoptosis of PCa cells, and stimulate anti-tumour immunity. Much of the confusion surrounding its seemingly paradoxical roles in cancer biology stems from the dependence of its effects on the biological model within which TNF is investigated. This review will address some of these issues, and also discuss on the therapeutic implications.

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ID Code: 55262
Item Type: Journal Article
Refereed: Yes
Keywords: tumour necrosis, tumour necrosis factor-alpha, prostate cancer, TNF signalling, Cytokine, Angiogenesis, epithelial to mesenchymal plasticity
DOI: 10.1155/2012/128965
ISSN: 2090-312X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Hindawi Publishing Corporation
Deposited On: 20 Dec 2012 00:12
Last Modified: 19 Oct 2014 16:09

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