Scaffolds for growth factor delivery as applied to bone tissue engineering

Blackwood, Keith A., Bock, Nathalie, Dargaville, Tim R., & Woodruff, Maria A. (2012) Scaffolds for growth factor delivery as applied to bone tissue engineering. International Journal of Polymer Science, 2012(174942), pp. 1-25.

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Abstract

There remains a substantial shortfall in treatment of severe skeletal injuries. The current gold standard of autologous bone grafting from the same patient, has many undesirable side effects associated such as donor site morbidity. Tissue engineering seeks to offer a solution to this problem. The primary requirements for tissue engineered scaffolds have already been well established, and many materials, such as polyesters, present themselves as potential candidates for bone defects; they have comparable structural features, but they often lack the required osteoconductivity to promote adequate bone regeneration. By combining these materials with biological growth factors; which promote the infiltration of cells into the scaffold as well as the differentiation into the specific cell and tissue type, it is possible to increase the formation of new bone. However cost and potential complications associated with growth factors means controlled release is an important consideration in the design of new bone tissue engineering strategies. This review will cover recent research in the area of encapsulation and release of growth factors within a variety of different polymeric scaffolds.

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16 citations in Scopus
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7 citations in Web of Science®

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ID Code: 55474
Item Type: Journal Article
Refereed: Yes
Keywords: Bone, Growth Factor, Polymers
DOI: 10.1155/2012/174942
ISSN: 1687-9430 (online) 1687-9422 (print)
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2012 The authors.
Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 11 Dec 2012 23:41
Last Modified: 07 Sep 2016 18:44

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